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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Rebekah Littleton Wilson and Brooke Stayer
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DOI:10.17265/2328-2150/2014.12.004
Objectives: The aim of this study was to assess the ability of a vancomycin nomogram to effectively predict vancomycin serum trough concentrations within the desired 15-20 mg/L therapeutic range. Methods: A retrospective chart review was performed on a randomized sample of trough concentrations from adult patients at HVMC (Holston Valley Medical Center) receiving intravenous vancomycin dosing regimens determined by the vancomycin nomogram over an eight-month span. Key findings: 102 patients were included in the study. Trough concentrations ranged from 3.5 mg/L to 40.8 mg/L with 36 (35.2%) patients having trough levels within the desired range of 15-20 mg/L. In addition, 75 (73.5%) patients had trough levels within the range of 10-25 mg/L. Conclusion: This study demonstrated that the vancomycin nomogram at HVMC is an effective dosing tool that provides consistency among multiple pharmacists and predictable serum trough concentrations.
Vancomycin, pharmacokinetic, nomogram, trough.
Wilson, R. L., and Stayer, B. 2014. “Evaluation of the Effectiveness of a Vancomycin Nomogram at Predicting Trough Levels within a Therapeutic Range.” Journal of Pharmacy and Pharmacology 2 (12): 713-721.