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In Vitro Antioxidant, Anticancer and Anti-cytotoxic Activity of Lippia alba



Author(s)

Jean Carlos Vencioneck Dutra, Victor Nogueira da Gama Kohls, Paula Roberta Costalonga Pereira, Jean Moisés Ferreira, Lucas Evangelista dos Santos, Maria Gabriela Pissinati Trindade and Maria do Carmo Pimentel Batitucci

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DOI:10.17265/2328-2150/2022.10.003

Lippia alba is a herb widely distributed in Latin America used in the traditional medicine. Considering that medicinal plants present anticancer action, the aim of the work was to verify the in vitro antioxidant, cytotoxic, anti-cytotoxic and anticancer effects of L. alba extract, correlating the results with phytochemical content. Phytochemicals were evaluated by spectrophotometry; antioxidant activity was evaluated by DPPH, ABTS and Fe²⁺ chelating activity. In vitro cytotoxicity and anti-cytotoxicity were evaluated in human lymphocytes and anticancer action was evaluated in sarcoma-180 cells. L. alba extract presents good antioxidant, antiproliferative and anti-cytotoxic effects. Total flavonoid content was correlated to the antiproliferative effect; total tannin content was correlates to ABTS antioxidant activity and to health cells maintenance. Tannins were also correlated to the prevention of cisplatin-induced damage. Our finds support the use of L. alba as a source of natural antioxidants and as a potent anticancer and anti-cytotoxic agent, reinforcing the use of natural products for health promotion.

Phenolic content, DPPH, ABTS, iron chelating, sarcoma-180, MTT assay.

Dutra, J. C. V., da Gama Kohls, V. N., Pereira, P. R. C., et al. 2022. "In Vitro Antioxidant, Anticancer and Anti-cytotoxic Activity of Lippia alba." Journal of Pharmacy and Pharmacology 10 (10): 256-262.