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Remediation of Hepatotoxic Effect of Tamoxifen with Ginger in Rat Model
Vanditha. S, Princy Louis Palatty, Malini Eapen, Thennavan. A, Manjeshwar. S. Baliga and Greeshma. C. Ravindran
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DOI:10.17265/2328-2150/2022.03.003
Background: Tamoxifen is a non-steroidal oestrogen receptor modulator. It has strong anti-estrogenic activity on oestrogen receptor 2 in the breast tissue. It is the treatment of choice in breast cancer cases following surgery and radiotherapy, it is the most potent weapon against breast cancer. All stages of hormone-dependent breast cancer are currently treated with tamoxifen. Long-term tamoxifen therapy may cause hepatotoxicity which would perclude the use of tamoxifen. Hence this study was done to determine whether ginger has a role in protecting liver toxicity caused by tamoxifen. Methods: Twenty female albino rats (SD) were divided into 4 groups. Each group formed of five rats: Group I: Serves as control group received normal rodent diet and water, Group Ⅱ: Received ginger powder (200 mg/kg) dissolved in normal saline, orally daily for 6 weeks, Group Ⅲ: received TAM at a dose of 20 mg/kg daily for 6 weeks orally Group Ⅳ: Received TAM (20 mg/kg) then after 2 hrs they are orally given Ginger powder (200 mg/kg) daily for 6 weeks. Results: Tamoxifen 20 mg/kg/day caused hepatotoxicity in rats. When ginger is added to tamoxifen there is no development of hepatotoxic features like: marked sinusoidal congestion in the lobules and lab parameters showed decrease in serum AST and ALT levels when compared to tamoxifen group levels. Conclusion: Ginger supplementation would reduce the incidence of hepatotoxicity & related adverse drug reactions among breast cancer patient on therapy.
Breast cancer, tamoxifen, ginger, raised liver enzyme levels, hepatotoxicity, hepatic sinusoidal congestion.
Vanditha. S., Palatty, P. C., Eapen, M., et al. 2022. "Remediation of Hepatotoxic Effect of Tamoxifen with Ginger in Rat Model." Journal of Pharmacy and Pharmacology 10 (3): 79-86.