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Chemical Characterization and Biological Potential of the Essential Oil of Eucalyptus globulus Labill



Author(s)

Nayara Soares de Mendonça Braga , Monizy da Costa Silva , Amanda Lima Cunha, Antônio Euzebio Goulart Sant’Ana, Luana Luzia Santos Pires and Aldenir Feitosa dos Santos

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DOI:10.17265/2328-2150/2018.12.001

Oxidation of lipids in various products, along with the growth of medically important pathogens, has led to a search for medicinal plants with antioxidant and antimicrobial activities. As a result, the aim of this study was to evaluate the antioxidant and antibacterial activity of the essential oil of Eucalyptus globulus (EO-Eg). Antioxidant activity was assessed by using the 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) assay method. Existing components were identified through gas chromatography-mass spectrometry (GC-MS) analysis. Antibacterial activity and minimum inhibitory concentration (MIC) were assessed by using the broth microdilution method with standard multidrug-resistant bacterial strains. The main EO-Eg compounds identified by GC-MS were isopulegol, citronellal, and citronellol, which are primarily used in the industrial sectors. EO-Eg demonstrated excellent antioxidant activity with an effective concentration (EC50) of 4.48 μL/mL owing to the presence of phenolic compounds. Regarding antibacterial activity, the EO-Eg displayed a broad antimicrobial spectrum of antimicrobial activity across the different resistance phenotypes analyzed. The most notable antibacterial activity was observed against Staphylococcus aureus 169 MRSA (MIC = 0.0625%). As a result, our findings suggest that EO-Eg has antioxidant and antibacterial potential against hospital-acquired multidrug-resistant pathogens, which may be correlated with its major components.

Essential oil, antioxidant, chemical identification, multidrug resistance, Eucalyptus globulus.

de Mendonça Braga, N. S., et al. 2018. “Chemical Characterization and Biological Potential of the Essential Oil of Eucalyptus globulus Labill.” Journal of Pharmacy and Pharmacology 6 (12): 979-988.