Contact us
 |
[email protected] |
 |
3275638434 |
 |
 |
| Paper Publishing WeChat |
Useful Links
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
Author(s)
Mohamed Ali Hasan Al-Duais1,3 and Yahya Saleh Mohamed Al-Awthan2
Full-Text PDF
XML 1077 Views
DOI:10.17265/1934-7391/2017.04.002
Affiliation(s)
1. Department of Biochemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia
2. Department of Biology, Faculty of Science, Ibb University, Ibb 70270, Yemen
3. Department of Chemistry, Faculty of Science, Ibb University, Ibb 70270, Yemen
ABSTRACT
SC (Saussurea costus) (Asteraceae) is a traditionally known and potent plant which is well
considered for its medicinal uses in different indigenous Indian systems of medicine. This study
was undertaken to investigate the
hepatoprotective effect of SC against liver injury induced by CCl4 intoxication. Animals were divided into five groups. Group I, served as normal
control. Group II received 2 mL CCl4/kg
b.w. diluted with olive oil, at 1:1 ratio on day 11. Groups III and IV were
pre-treated orally respectively with 100 and 200 mg/kg b.w. aqueous roots extract
of SC for 10 days followed by subcutaneous injection of CCl4 (2 mL/kg b.w.), once on
day 11. Group V were orally given Liv-52 (100 mg/kg b.w.) once daily for 10 days followed by subcutaneous injection of CCl4 (2 mL/kg b.w.), once on
day 11. Our results show that, the activity of serum hepatic enzymes (ALT, AST,
and ALP) were significantly elevated in guinea pigs treated with CCl4,
while both the SC root extract and
Liv-52 reduced significantly these enzymes activity. Also, the levels of
glucose, urea and cholesterol were
decreased when compared with intoxicated control. Histopathological examination
of intoxicated animals showed dilation, hemorrhage, vacuolization, inflammation
and necrosis indicating liver damage, while the animals received SC or Liv-52 that showed less
pathological effects or normal liver when compared to animals treated with CCl4 alone. Biochemical and histological results confirm the hepatoprotective effect
of aqueous extract of SC.
KEYWORDS
Saussurea costus, CCl4, hepatotoxicity, extract, Liv-52, histopathology, biochemistry.
Cite this paper
References