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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
Author(s)
Elizabeth B. F. Lainetti1, Luiz Augusto C. Passos2, Carlos R. J. Soares3 and Nanci do Nascimento3
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DOI:10.17265/1934-7359/2016.08.003
Affiliation(s)
1. Infrastructure Department, Nuclear and Energetic Research Institute (IPEN-CNEN/SP), São Paulo/SP. CEP 05508-000, Brazil
2. Multidisciplinary Center for Biological Investigation on Laboratory Animal Science—CEMIB, Campinas State University—UNICAMP, Campinas/SP, CEP 13083-877 , Brazil
3. Biotechnology Department, Nuclear and Energetic Research Institute (IPEN-CNEN/SP), São Paulo/SP. CEP 05508-000, Brazil
ABSTRACT
The use of Animal House Facilities of IPEN-CNEN/SP (Nuclear and Energetic
Research Institute—National Nuclear Energy Commission/SP, Brazil) has provided rats
and mice with controlled sanitary quality for research and quality control in
the production of radiopharmaceuticals lots, produced at IPEN, following rules
of CONCEA—Brazilian National Council for Animal Experimentation Control and
approved in CEUA (Ethics Committee on
the Use of Animals), before they are sent to hospitals
and clinics spread out in Brazil, for use in nuclear medicine. The production
and the supply of high quality laboratory animals have fundamental importance
for the accomplishment of vanguard scientific research, with reproducibility
and universality. The quality of those animals depends, largely, on the available facilities
for their production and lodging, to assure the demanded sanitary control and
animal’s welfare, in agreement with the ethical principles that control the
activity. Therefore, the facilities design is of vital importance so that the
mentioned requirements can be reached. Nevertheless, pigs and miniature pigs
have gained importance as large animal models in medicine. With their size,
organ capacity, and physiology resembling in several aspects that of humans,
pigs are well suited for preclinical experiments and long-term safety studies. Minipigs will be used
for preclinical testing of radiopharmaceuticals and assays radioactive
materials for cardiac tests. This paper describes the premises and preliminary
activities that have been performed at IPEN for the design of new Animal House
Facilities dedicated to keeping minipigs taking into account fundamental
aspects such as: animal’s welfare, sanitation, genetic, in agreement with the
ethical principles that control the activity and environmental concerns.
KEYWORDS
Research animals, minipigs, housing, facility, design, conceptual proposal.
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