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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
Hydroxy Propyl Methyl Cellulose: Different Aspects
in Drug Delivery
Author(s)
Tamasree Majumder, Gopa Roy Biswas and Sutapa Biswas Majee
Full-Text PDF
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DOI:10.17265/2328-2150/2016.08.003
Affiliation(s)
ABSTRACT
Among the various research
works going on nowadays, designing of controlled release dosage form is of
great importance. For the development of suitable controlled release dosage
form, a proper matrix needs to be formed from
which the drug release generally occur by polymer swelling, polymer erosion,
drug dissolution/diffusion mechanism. HPMC (hydroxy
propyl methyl cellulose), also known as
hypromellose, is one of the best
known cellulosic polymers used in the development of controlled released drug
delivery. It is available in various grades. Cellulosic polymers are
ingredients that contain units linked together which help to retain water. Due
to its high water absorptive capacity, it acts as an excellent hydrophilic gel
forming polymer. HPMC generally hydrates on the outer surface to form a
gelatinous layer which is critical to prevent wetting and rapid drug release
from the matrices. If the drug is sparingly soluble in the system, the release
of drug from the system is slow and helps in formulation of controlled release
dosage form. In the ophthalmic dosage form, HPMC is used as a matrix that
swells and expands after absorbing water and expand the thickness of the tear
film.
KEYWORDS
HPMC, hypromellose, hydrophilic, controlled released dosage form.
Cite this paper
Majumder, T., Biswas, G. R., and Majee, S. B. 2016. “Hydroxy Propyl Methyl Cellulose: Different Aspects in Drug Delivery.” Journal of Pharmacy and Pharmacology 4 (8): 381-385.
References