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Facile Synthetic Design and Characterization of Curcumin-Metformin Adduct: Potential Insights into the Role of This Conjugate in Diseases of Aging



Author(s)

Bishambar Dayal, Apexa Mehta, Abhimanyu Teja Yarramaneni, Biren Patel, Sagar Patel, James Patrick O’Connor, Michael Anthony Lea and Jesse Chou

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DOI:10.17265/2162-5263/2016.03.004

Recently, the anti-glycation and anticancer properties of curcumin longa and okra seed extract were studied alone and also in combination with the well-established drug metformin. The combined effect of curcumin with metformin and metformin with okra seed extract was found to be highly efficacious in inhibiting Advanced Glycation End-products (AGEs). In order to understand the mechanistic implications of curcumin combined with metformin and its enhanced anti-glycation activity, a Curcumin-Metformin Adduct was chemically synthesized. This adduct was fully characterized by thin-layer chromatography, Nano Drop spectrophotometry and electrospray-ionization mass spectrometry. The adduct may be helpful not only in elucidating the mechanism of anti-glycation and anti-cancer activities but also in studying the role of curcumin in binding of Aβ-oligomers and disaggregating fibrillar formation in Alzheimer’s disease.

Curcumin, metformin, diabetes, anticarcinogenic