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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
EEG (Electroencephalography) Abnormality in First Episode Mania: Is It Trait or State?
Author(s)
Sermin Kesebir, Sertaç Güven, Elif Tatlıdil Yaylacı, Özgür Bilgin Topçuoğlu, Merih Altıntaş
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DOI:10.17265/2159-5542/2013.10.002
Affiliation(s)
Erenköy Mental and Neurological Disease Training and Research Hospital, İstanbul, Turkey
ABSTRACT
The
aim of this study is to investigate the frequency of abnormal EEG (electroencephalography)
findings in first episode mania and to determine whether EEG abnormality
improves at the subsequent remission period. The secondary, to compare cases
with or without abnormal EEG findings with regard to clinical characteristics
of BD (bipolar disorder). In the present study, 86 consecutive first attack
mania cases between the ages of 18-65 diagnosed as BD, manic
episode according to DSM-IV who referred to our outpatient clinic or emergency
service whose informed consent form was signed by first degree relatives were
evaluated. Inclusion criteria were not having previous depressive episode, absence of any neurologic
disorder, especially epilepsy, absence of history head trauma, and/or loss of
consciousness and were not using any drugs which can influence
electroenecepholafraphic activity before EEG (antiepileptic, anxiolytic,
antidepressant, and antipsychotics). Diagnostic interviews were made with SCID-I
(DSM-IV Structured Clinical Interview) and information on disease was recorded
with SKIP-TURK (Mood Disorder Diagnosis and Follow-up Form). EEG recordings
were made with digital EEG device in 16 channels. EEG abnormality is more frequent in mania than remission
period (p = 0.022) and occurs at the rate of 28.7%. All cases with continuing abnormal EEG
findings in remission period are women. In cases
with continuing EEG abnormality, the age of menarche is smaller (p = 0.032) but family history is less
frequent (p = 0.008). Childhood
trauma and history of suicide attempt is more frequent in cases with abnormal
EEG in remission period as well (p <
0.001 and 0.005). Of the cases, whose abnormal EEG improved in remission period, 83.3% were treated
with anticonvulsants. In some bipolar cases, abnormal EEG is present from the
onset of disease and it is associated with some clinical characteristics.
Abnormal EEG returns to normal in half of the cases in remission period.
KEYWORDS
first episode, mania, remission, EEG (electroencephalography)
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