Affiliation(s)
1. Food Technology Departement, Pasundan University, Bandung, Indonesia
2. Pharmacology-Clinical Pharmacy, School of Pharmacy, Institute Technology Bandung, Indonesia
3. Pharmaceutical Chemistry Research Group, School of Pharmacy, Institute Technology Bandung, Indonesia
ABSTRACT
The aim of the study was to
investigate antihyperuricemic effect of snake fruit (Salacca edulis Reinw.) var. Bongkok Wistar male rates.
Antihyperuricemic investigation on Wistar male rats showed that administration
of ethanol extract at doses of 200 mg/kg bw decreased serum uric acid level
significantly compared to control group at hour 6 and 7 (P < 0.05) after inducing with potassium oxonate
intraperitoneally simultaneously with uric acid orally. Whereas, administration
of ethanol extract at doses of 100 mg/kg bw did not decrease serum uric acid
level significantly different compared to control group at hour 6 and 7 (P < 0.05). Determination of uric acid level in
urine, administration of ethanol extract at a dose of 200 mg/kg bw, or
probenecid as a standard drug, at a dose of 45 mg/kg bw increased excretion of
urine uric acid level significantly different compared to control group in day
of 7 (P < 0.05) after inducing with potassium oxonate
intraperitoneally simultaneously with uric acid orally. However, increase of
uric acid excretion by ethanol extract was lower compared to that of probenecid
at a dose of 45 mg/kg bw. Mechanism of action of the ethanol extract as an
antihyperuricemia has been proposed by inhibition of xanthine oxidase and
finally decreased the synthesis of uric acid and increased the excretion of
urine uric acid level.
KEYWORDS
Snake fruit var., Bongkok, ethanol
extract, antihyperuricemic, probenecid, Wistar
male rat.
Cite this paper
References