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Synthesis of the dl-ξ-Thiotocopherol: Newest Derivative of the dl-α-Tocopherol



Author(s)

Tunçer Mutlu¹, İbrahim Erol², Nevin Mutlu³ and Levent Özcan⁴

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DOI:10.17265/1934-7375/2012.01.013

1. Department of Chemical Engineering, Engineering Faculty, University of Kocatepe, ANS Campus, Afyonkarahisar 03030, Turkey
2. Department of Organic Chemistry, Science and Art Faculty, University of Kocatepe, ANS Campus, Afyonkarahisar 03030, Turkey
3. Department of Chest and Tuberculosis, City Government Hospital, Gemlik 16600, Turkey
4. Department of Analytical Chemistry, Science and Art Faculty, University of Kocatepe, ANS Campus, Afyonkarahisar 03030, Turkey

Tocopherol is the most active vitamin and natural antioxidant existing in the nature known as vitamin E. Lacking of this vitamin makes drastic exchanges on the health of the living organisms. Their active chemical form is l-α-tocopherol substance. In this article, α-thiotocopherol a tocopherol derivative was synthesized via a precursor like dl-α-tocopherol, which has better antioxidant than natural α-tocopherol. And the last compound after separation and purification via TLC and PC procedures was analyzed by FTIR, GC-MS and elemental analysis, oxidative stability is tested with TGA method in air showing roughly antioxidant effect. Another approach is measurment of redox potential against a reference electrode under inert nitrogen atmosphere.

Tocopherol, phenols, substitute phenols, thiotocopherol, redox potential, thermal and oxidative stability.