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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
Erythrocyte Toxicities of Imidazolidinyl Urea and Diazolidinyl Urea
Author(s)
Halla Noureddine, Boucherit Kebir, Boucherit Zahia and Rahmoun Nadjib
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DOI:10.17265/2161-6221/2013.07.006
Affiliation(s)
Antibiotics Antifungal Laboratory, Physical Chemistry, Synthesis and Biological Activity, Department of Molecular and Cellular Biology, Abou Bekr Belkaïd University, Tlemcen 13000, Algeria
ABSTRACT
The addition of antimicrobial preservatives to pharmaceutical and cosmetic products is necessary to prevent microbial growth. However, the use of preservatives can also produce other undesirable effects. For several years, researchers have been investigating the use of alternative methods in safety assessment of cosmetic ingredients and formulations by means of variety methods. The aim of this study was to evaluate the erythrocyte toxicities of two commercial preservatives: imidazolidinyl urea and diazolidinyl urea. Relatively few studies about the cytotoxicity of these preservative are available. The determination of their cytotoxicity is an essential step to warrant their safe use. Erythrocyte toxicities were evaluated by assessment of the amount of hemoglobin released by red blood cells after their lysis. In this study, both imidazolidinyl urea and diazolidinyl urea showed cytotoxic activity against red blood cells. The imidazolidinyl urea induce a small release of hemoglobin after 120 min of incubation. But, the diazolidinyl urea induce a massive release of hemoglobin from the imidazolidinyl urea (a rate of 83% at concentrations of 6.25 mg/mL and 12.5 mg/mL).
KEYWORDS
Erythrocyte toxicity, imidazolidinyl urea, diazolidinyl urea, preservative, cosmetic.
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