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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
Author(s)
Maike Bargmann1, Hans Kothe1, Bernd Steinhoff1, Ingo Alig1, Claudia Rode2, Ralf Wyrwa2 and Matthias Schnabelrauch2
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DOI:10.17265/2161-6221/2013.10.001
Affiliation(s)
1. FraunhoferInstitute for Structural Durability and System Reliability LBF, Darmstadt 64289, Germany 2. INNOVENT e.V., Prüssingstrasse 27B, 07745 Jena, Germany
ABSTRACT
The influence of material composition and melt processing on filler dispersion, molar mass degradation, thermo-mechanical properties, biodegradability and cytocompatibility have been studied for composites of polylactide (PLA) and
different biodegradable inorganic filler materials (e.g. calcium phosphate, calcium carbonate, pure and functionalized hydroxyapatites) as well as different filler amounts-varying from 0 to 40 wt.%. Due to their thermoplastic processability, biocompatibility and biodegradability the studied materials serve as model compounds for PLA-based orthopedic implant materials used in bone repair. Polymeric matrix material and fillers were melt-mixed using either a micro- or a laboratory-scale extruder. Test samples were prepared by injection molding of the compounds and characterized by gel permeation chromatography (GPC), differential scanning calorimetry (DSC), dynamical-mechanical analysis (DMA), micro computer tomography (μ-CT) and wide-angle X-ray scattering (WAXS). All measurements regarding mechanical properties show the samples to be suitable for non-load-bearing orthopedic applications. Cell colonization experiments with MC3T3-E1 and RAW 264.7-cells were performed and showed all samples to be cytocompatible, irrespective of the chosen filler type. Biodegradation and process-induced degradation of the molar mass were found to be slower for samples containing hydroxyapatite than for those containing calcium carbonate or calcium phosphate.
KEYWORDS
Polylactide composites, inorganic fillers, implants, melt processing, thermo-mechanical properties, degradation,
biodegradability, cytocompatibility.
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