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The Frequency of Y Alu Polymorphism (YAP) Indel in the Minangkabau Malays in Peninsular Malaysia



Author(s)

Wan Nurhayati Wan Hanafi, Muhd Shah Jehan Abd Razak, Azzura Abdullah, Nor Hazwani Ghani, Nur Azimah Osman and Farida Zuraina Mohd Yusuf

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DOI:10.17265/1934-7391/2014.09.008

Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), Shah Alam, Selangor 40450, Malaysia
Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM) Cawangan Negeri Sembilan, Kuala Pilah 72000, Malaysia

Background: Minangkabau Malays (Melayu Minangkabau) is one of the Malay sub ethnic groups in Peninsular Malaysia. During the late 17th and early 18th centuries, migration of the Minangs from West Sumatra to the state of Negeri Sembilan Darul Khusus in Peninsular Malaysia took place and their descendants now form the main sub ethnic group in this state. The genetic polymorphisms of Y chromosome at DYS 287 locus were analyzed in Minangkabau Malays. Methods: A total of 41 buccal cells from healthy unrelated individual’s males from Minangkabau Malays were typed for the DYS 287. The PCR products were separated on 2% (w/v) agarose gel followed by visualization under UV light. Results: Three out of 41 samples (7.32%) showed insertion (YAP+) polymorphism, while the rest of the samples (92.68%) showed deletion (YAP-) polymorphism. This is the first report concerning the YAP in Malay population at Peninsular Malysia. Conclusion: The vAluable data obtained in this study will contribute to fill in the gap in the knowledge of YAP distribution in Malaysian population and will allow continuous interpretation of the evolution of YAP.

Y Alu insertion polymorphism (YAP), DYS 287, FTA, PCR, Minangkabau Malays.