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The Antitumor Effect of Rhamnetin on the Heart



Author(s)

Seher YILMAZ¹, Züleyha DOĞANYİĞİT², Adem TOKPINAR¹, Özlem BOZKURT³, Aslı OKAN OFLAMAZ², Rabia KURT TOKPINAR⁴, Şükrü ATE޹

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DOI:10.17265/1548-6648/2021.03.005

1. Yozgat Bozok University, Faculty of Medicine, Department of Anatomy, Yozgat, 66100 Turkey
2. Yozgat Bozok University, Faculty of Medicine, Department of Histology-Embryology, Yozgat, 66100 Turkey
3. Nevşehir Hacı Bektaş Veli University, Faculty of Dentistry, Nevşehir, 50100 Turkey
4. Yozgat Bozok University, Faculty of Medicine, Department of Obstetrics and Gynecology Yozgat, 66100 Turkey

Rhamnetin has a wide usageduetoits anti-inflammatory, anti-carcinogenicand anti-oxidantproperties. In this study, the effects of different doses of Rhamnetin on ascitetumor were investigated in the Ehrlich Assit Tumor (EAT) model originating from mouse breast adenocarcinoma and developed in Balb / c mice.

Inthisstudy  10Balb / c mice were used each group, six of them were in stock animals and the others were in ascitestumor groups. EAT cells (1x10⁶ EAT cells) taken from all stock mice were injected intraperitoneally. 200 μg /kg rhamnetin was administered intraperitoneally to the treatment groups of animals with ascites tumor for 10 days. At theend of the experiment, the animals were decapitated and the hearts of the animals were removed and determined orhistological evaluation.

The histological results of hearttissues of ascitestumor-induced animals were observed to be less in the 200 μg / kg rhamnetin treated group compared to the tumor control group than EAT cells (p <0.05).

It has beenshown in our study that  rhamnetin has antitumoral effect on ascitetumor development with EAT cells.

EAT, rhamnetin, cell, anti-inflammatory.