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The Vibrational Behavior of the Mixture Quercetin/Gelucire 50/13 at Room and Body Temperature



Author(s)

M. El Hadri¹, B. Khelifa^2,5, V. Faivre³, O. Abbas⁴ and S. Bresson⁵

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DOI:10.17265/2161-6221/2021.7-9.002

1. Laboratory of Condensed Matter Physics, Abdelmalek Essaâdi University, Tetouan 93000, Morocco
2. Faculty of Science, University of Artois, Lens 62300, France
3. Polyphase Systems Physical Chemistry Team, UMR CNRS 8612, Labex LERMIT, University of Paris Sud, Paris 75000, France
4. Walloon Agricultural Research Centre (CRA-W), Valorisation of Agricultural Products, Department, Food and Feed Quality Unit (U15), Gembloux 5030, Belgium
5. Institut Polytechnique UniLaSalle, Université d’Artois, ULR 7519, 19 Rue Pierre Waguet, BP 30313, Beauvais 60026, France

The present paper discusses the vibrational properties of the mixture gelucire-quercetin (from 1% to 5%) at room and body temperature. Quercetin is a flavonoid having beneficial properties: biological and antioxidant; it is used in many fields as food, cosmetic and especially pharmaceutics but its use as a drug is affected by its low solubility. The Gelucire 50/13 is used as sustained release matrix forming agent in pharmaceutical applications and it has demonstrated the ability to improve the dissolution as well as the absorption of poorly water-soluble drugs. The mixture Gelucire-quercetin was essentially studied by FTIR (Fourier transform infrared spectroscopy) and Raman spectroscopy. The behavior of these two molecules has been investigated in the spectral range 4000-0 cm^-1 in Raman spectroscopy, and 4,000-600 cm^-1 in FTIR.

Gelucire 50/13, quercetin, solubility, Raman spectroscopy, IR spectroscopy.