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Radiation-Induced Synthesis of Polyvinylpyrrolidone (PVP) Nanogels



Author(s)

Adrian Alejandro Ges Naranjo1, HerlysViltres Cobas1,2, Danaydis Fonseca Rogdriguez3, Manuel Rapado Paneque4 and Yuri Aguilera Corrales1

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DOI:10.17265/2159-5348/2016.05.004

1. Higher Institute of Technologies and Applied Science, Nuclear Development and Technological Applications Centre, La Habana, Cuba 2. Center of Research in Applied Science and Technology Advanced, Legaria-Unit, Polytechnic National Institute, Ciudad de Mexico, Mexico 3. Finlay Institute, La Habana, Cuba 4. Center for Technological Applications and Nuclear Development, La Habana, Cuba

Nanogels—particles of polymer gels having the dimensions in the order of nanometers—are gaining attention for their wide application as biomaterials. Mainly, the nanogels are promising novel pharmaceutical carriers for small biologically active agents, bio macromolecules and can be chemically modified to incorporate various ligands for targeted drug delivery. This important factor has stimulated research on dissimilar science field such as nanotechnology and biotechnology, polymer and materials sciences, biochemistry, radiation chemistry and pharmaceutical sciences. A multitude of techniques have been described for the synthesis of this nanomaterial from polymers. However, the use of ionizing radiation (γ, e-) has demonstrated to be especially suitable for obtaining polymeric nanogels with a high degree of purity for biomedical applications, although the gamma radiation has not been widely utilized for these purposes. The aim of this paper is to develop the synthesis of PVP (polyvynilpyrrolidone) nanogels by gamma irradiation, for their evaluation as potential pharmaceutical carriers. Experiments were performed using argon saturated solution of PVP (0.1-1%). Crosslinking reactions were carried out in a gamma irradiation chamber with a ⁶⁰Co source (ISOGAMMA LLCo), at room temperature. The PVP concentration influence was evaluated in PVP solutions (0.1% and 0.25%) at 15 kGy. The SEM (scanning electron microscopy), ATR (attenuate total reflection spectroscopy), DLS (dynamic light scattering), and viscosimetry were used as characterization techniques.

Polyvynilpyrrolidone nanogels, gamma irradiation, biomaterial.