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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
Author(s)
Bishambar Dayal1, 2, Apexa Mehta2, Sagar Patel2, Dhaval Shah2, Priyanka Chitkul2 and Michael Anthony Lea2
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DOI:10.17265/2162-5298/2016.06.002
Affiliation(s)
1. Department of Medicine, Rutgers University-New Jersey Medical School, Newark, New Jersey 07103, USA
2. Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University-New Jersey Medical School Newark, New Jersey 07103, USA
ABSTRACT
Recently microwave-induced chemical synthesis of curcumin-metformin
adduct to enhance the efficacy of metformin in preventing the formation
ofAdvanced Glycation End Products (AGEs) has been reported from authors’ laboratory. The present
studies describemicrowave-induced chemical synthesis and mass spectral
characterization of curcumin-phenformin adducts using LC-MS/MS. The mechanism of formation and its analytical data via
Thin-Layer Chromatography (TLC) combined with MS/MS
fragmentation revealed a major six membered ring adduct and a minor eight
membered ring isomer. A facile chemical synthesis and identification of major
and minor isomers presented in this study may offer novel therapeutic
strategies for inhibiting AGEs as well as anti-cancer treatments.
KEYWORDS
Diabetes mellitus, advanced glycation end- products, glycated human serum albumin, curcumin, phenformin, metformin, anti-cancer agents.
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