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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
Antibiotic-Loaded Resorbable Bone-Graft Substitute:
A New Treatment for Osteomyelitis/Osteitis
Author(s)
Bernd Gächter, Jennifer Frieda Angehrn, Stephane Schlunke, Sebastian Probst and Paul Biegger
Full-Text PDF
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DOI:10.17265/2328-2150/2016.08.008
Affiliation(s)
ABSTRACT
Patients with osteomyelitis require lengthy antibiotic treatment, often
only to see the inflammation flare up once antibiotics are suspended.
Unfortunately, patients often discontinue the antibiotic treatment due to
collateral effects. Patients with osteitis are often polymorbid patients with
other severe diseases such as diabetes mellitus and polyneuropathy, arteriopathy or
polyarthritis with immunosuppression. The eight patients included in the study
presented nine bones with osteomyelitis (macroscopically, bacteriologically, histologically or radiologically). The diseased part of
the bone was resected, a locally radical debridement was done and a biopsy for
bacteriology and histology were taken. The residual bone was then drilled out
and filled with antibiotic-loaded (gentamicin) resorbable bone-graft substitute
under radiologic imaging control. In total, seven
patients are currently without recurrent osteomyelitis with a mean follow-up of
5.77 months (2~11 months). The Kaplan
Meier curve shows 80% survival rate without recurrent osteomyelitis at 11 months. Only one patient
suffering from Morbus Buerger had a relapse osteomyelitis after cutting off
severing his foot while swimming in the sea. Antibiotic-loaded resorbable
bone-graft substitute is easy to use, has in our hands few complications and
low recurrence rate.
KEYWORDS
Osteomyelitis, bioabsorbable antibiotic carrier, bone-graft substitute.
Cite this paper
Gächter, B., et al. 2016. “Antibiotic-Loaded Resorbable Bone-Graft Substitute: A New Treatment for Osteomyelitis/Osteitis.” Journal of Pharmacy and Pharmacology 4 (8): 405-412.
References