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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
Biodegradable Protection for Medical Devices with Medical Drugs Controlled Separation
Author(s)
Milentina V. Seregina, Evgeny А.Nemets, Alina A. Akhmedova, Pavel B. Kurapov and Elena Yu. Bachtenko
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DOI:10.17265/2328-2150/2016.05.005
Affiliation(s)
ABSTRACT
With the aim of creating biodegradable materials for medical devices clinical appointments with high hemocompatibility we have developed a new polymer product.The basis of this product is plasticized by polyethylene glycol bacterial copolymer of hydroxybutyrate and oxovalerate. A well-known antithrombotic supplement—acetylsalicylic acid has been added to improve hemocompatibility in the polymer. The results of our studies showed a controlled prolonged separation of acetylsalicylic acid from polymeric material in the blood. We studied in vitro the dynamics of liberation of acetylsalicylic acid from polymeric coatings. It was shown that the concentration of polyethylene glycol and the thickness of the polymer layer can affect the rate of diffusion of acetylsalicylic acid from polymer films.
KEYWORDS
Bacterial biodegradable copolymers, poly (hydroxybutyrate-co-oxovalerate), hemocompatible, medical devices for clinical application, polyethylene glycol, acetylsalicylic acid.
Cite this paper
Seregina, M. V., et al. 2016. “Biodegradable Protection for Medical Devices with Medical Drugs Controlled Separation.” Journal of Pharmacy and Pharmacology 4 (5): 226-230.
References