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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
Effect of Doxorubicin on Histomorphology of Liver of Wistar Albino Rats
Author(s)
Deepak Chaudhary, Saroj Khatiwada, Surendra Kumar Sah, Man Kumar Tamang, Soumya Bhattacharya and Chandra Bhushan Jha
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DOI:10.17265/2328-2150/2016.04.005
Affiliation(s)
ABSTRACT
Doxorubicin is associated with adverse effects on organs like liver. This study was done to find the effects of doxorubicin on liver of wistar albino rats. Sixty healthy wistar albino rats were taken for the study. The rats were randomly divided in to 4 groups (2 experimental groups; group A1 and A2, and 2 control groups;group B1and B2 each containing 16 rats). The experimental groups were given a single dose of doxorubicin i.e. 10 mg/kg body weight intraperitoneally and sacrificed after 7 days and 14 days for each group. Rats under control groups were given a single intraperitoneal dose of 2.5 ml/kg body weight normal saline and sacrificed with their respective experimental groups. A significant difference (p < 0.001) and (p = 0.005) in final body weight was observed among group A1 experimental and B1 control rats, and among group A2 experimental and B2 control rats. As compared to group B2 control, group A2 experimental rats had significantly (p = 0.043) lower liver weight. Diameter of hepatocyte (p < 0.001 for both groups) and nucleus (p=0.004 for group A1 and control B1, and p < 0.001 for group A2 and control B2) was significantly higher in experimental rats as compared to their respective controls. Cross-sections of the liver of both control groups had normal architecture. However, there was progressive destruction of liver architecture across the experimental groups. Doxorubicin causes the disruption of normal architecture of liver in rats. Thus care needs to be taken during doxorubicin chemotherapy to minimize effects on liver.
KEYWORDS
Doxorubicin, Histomorphometry, Liver, Wistar albino rat.
Cite this paper
Chaudhary, D., et al. 2016. “Effect of Doxorubicin on Histomorphology of Liver of Wistar Albino Rats.” Journal of Pharmacy and Pharmacology 4 (4): 174-178.
References