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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
Examination of the Stability of Amoxicillin in Compounded Suppositories and Ointments
Author(s)
Małgorzata Zdzieborska , Ewa Siedlecka and Izabela Orłowska
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DOI:10.17265/2328-2150/2016.02.003
Affiliation(s)
ABSTRACT
We examined the stability of amoxicillin trihydrate from the preparation Augmentin in compounded forms of drugs such as vaginal suppositories and ointments. The quantity of the antibiotic in the preparations studied was determined directly after they had been made and after a lapse of 7 and 14 days. We also carried out comparative examinations of the stability of sodium amoxicillin (Tarommentin) and sodium ampicillin (Ampicillin) in ointments with an addition of a boric acid solution. The examinations confirmed the stability of amoxicillin trihydrate in suppositories and in anhydrous and hydrated ointments. The content of this antibiotic in ointments with an addition of a boric acid solution decreases slightly. Comparative studies of the stability of sodium amoxicillin and sodium amoxicillin revealed a markedly lower stability of the two antibiotics in comparison to the stability of amoxicillin trihydrate.
KEYWORDS
Amoxicillin, ampicillin, vaginal suppositories, ointments, stability
Cite this paper
Zdzieborska, M., Siedlecka, E., and Orłowska, I. 2016. “Examination of the Stability of Amoxicillin in Compounded Suppositories and Ointments.” Journal of Pharmacy and Pharmacology 4 (2): 64-72.
References