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Simple, One Pot Synthesis of 3,4-Dihydropyrimidin-2-ones under Microwave Irradiation Using EPIC Catalyst



Author(s)

Makone Sangita Sanjay, Bunnawar Laxman Yeshwantrao and Niwadange Sandeep Nivruttirao

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DOI:10.17265/2161-6213/2011.07.012

Chemistry Research Lab., School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded 431606, Maharashtra, India

A general and practical route for the synthesis of 3, 4-dihydropyrimidinones by one pot cyclocondensation of aldehydes and b-ketoesters and urea is described using EPIC as catalyst in eco-friendly solvent, water under microwave irradiation. Use of alternate energy source such as microwave accelerates the rate of formation of the Biginelli product. Excellent yields, wide applicability, short reaction time and environmentally benign reaction conditions are important features of this method. The present method provides a novel and improved protocol for synthesis of 3, 4-dihydropyrimidinones.

3,4-Dihydropyrimidinones, EPIC, microwave irradiation, aqueous media.